Collaborative visit explores nature’s antibiotics

KUCHING: The Sarawak Biodiversity Centre (SBC) recently hosted a three-day visit from the National Centre for Genetic Engineering and Biotechnology (BIOTEC), which is a prominent institution under Thailand’s National Science and Technology Development Agency (NSTDA).

The purpose of this collaborative visit, held from July 10 to 12, was to explore a nature-based solution to combat antibiotic-resistant bacteria.

During the visit, the focus was on antimicrobial peptides (AMP), which naturally occur in the genomes of algae found in Sarawak. These peptides are derived from proteins translated from the DNA sequences in these algae genomes.

In a statement, the institutions expressed their joint effort to uncover valuable genetic traits that could be utilised for innovative biotechnological applications, including the development of pharmaceuticals and biologics to combat deadly pathogens.

BIOTEC contributed its expertise in genomic screening technologies and bioinformatics tools, while SBC provided access to the genomes of algae from its library.

With over 600 species of algae in SBC’s library, this collaboration has the potential to unveil new therapeutics.

This partnership highlights the significance of international collaboration in advancing genomic research, sharing technology, and addressing the urgent need to combat antimicrobial resistance (AMR).

SBC and BIOTEC remain committed to scientific excellence and innovation, playing a crucial role in driving progress and development on a global scale.

Dr Apiradee Hongsthong, the Principal Researcher of BIOTEC’s Biochemical Engineering and System Biology Research Group, emphasized the presence of valuable hidden information within genome sequences.

She mentioned their AI-based platform for identifying and predicting bioactive peptides, which can extract such information. For instance, the platform can determine the potential of algae as a protein source for antimicrobial peptide production.

The initial phase of the partnership will focus on effectively utilizing Sarawak’s native microalgae to develop new products that can combat antibiotic resistance, which impacts the environment, human health, and the economy.

Dr Yeo Tiong Chia, the CEO of SBC, highlighted that the collaboration between SBC and BIOTEC aligns with the Global Action Plan, which recognizes the critical need to address antimicrobial resistance.

The World Health Organization (WHO) has identified antimicrobial resistance as one of the most significant global health challenges of the 21st century.

Sarawak’s rich biodiversity, including algae and other biological resources, presents opportunities for exploration and research in this field.